If you're curious about what we've been building and how we're making an impact, Udayan Umapathi - Volta's Founder and CEO - talked with VentureFizz founder Keith Cline about everything from the technology to our incredibly talented team that makes it all possible. Check out this video interview to discover Volta Labs.
Discover Volta Labs
During this video interview, Udayan and Keith go deeper into how Volta Labs has evolved and why the team is tackling one of the biggest challenges facing the genomics industry:
- How is the Callisto Sample Prep System positioned to address the sample prep bottleneck?
- Why is sample prep automation necessary to advance the future of genomics and NGS?
- How is the company growing and evolving with the commercialization of Callisto?
- What is it like to work at Volta Labs?
- Why should Volta Labs be on the radar for job seekers?
"More than half of the sequencing industry is processing samples by hand," said Udayan Umapathi. "Callisto is the first platform that can go from raw biological samples to sequenceable molecules for pretty much every commercially available sequencing technology on the market."
Walk-away sample prep for any sequencer
The talented team of biologists, bioengineers, physicists, mechanical engineers, electrical engineers, software engineers, and manufacturing engineers at Volta are building a disruptive technology platform to go from raw biological samples to sequencing-ready libraries. The Callisto™ Sample Prep System, Volta's novel benchtop sample prep instrument, is preloaded with apps that require no user programming or optimization, bringing the push-button experience of a sequencer to sample prep. Learn more about the Volta Apps and application development for Callisto in this video interview with Abdul Mohammed.
Join our team of innovators and disruptors
Our team is growing quickly and we have roles open across a variety of disciplines. We're looking for exceptional humans to join our team - you could be next! Take a look at our open opportunities and apply to any that fit your experience and skillsets.
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Introducing VoltaHyb:
Automating the Last Mile of Targeted Sequencing Workflows
The Volta Labs team is revolutionizing critical targeted sequencing workflows with the introduction of the VoltaHyb™ suite of Apps and kits for the Callisto™ Sample Prep System. Designed to enrich your targets with confidence every single time, the Callisto platform brings unmatched workflow simplicity to hybridization capture. With Callisto, users no longer need to rely on multiple lab instruments (heated blocks, magnetic racks, vortexers) or perform time-sensitive heated transfer steps - such complex steps are abstracted away from the end user. Furthermore, Callisto's unique architecture enables precise magnetic bead manipulation coupled with uninterrupted and uniform temperature control during the hybrid capture enabling consistent enrichment performance.
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Callisto reduces sequencing redo rates to less than 3% while minimizing sample loss throughout the capture process. This breakthrough approach enables reliable targeted sequencing even for challenging applications where conventional tools struggle. These advantages extend across both long and short read-based hybrid capture workflows.
The scalable architecture of the Callisto system enables flexible throughput, with the capacity to process up to 96,000 exomes per year or 48,000 PacBio HiFi samples annually. Whether you're running a small research lab or a high-volume testing facility, Callisto adapts to your needs with flexible batch sizes and consistent performance.
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Key Benefits
of VoltaHyb for Hybridization Capture:
Reduced Sequencing Costs:
Lower sample preparation and sequencing costs by minimizing reruns (<3% redo rates).Fully Automated Workflow:
Enables complete walk-away automation for hybridization, capture, washes, and PCR setupBroad Panel Compatibility:
Works with panels of all sizes, from small targeted panels to comprehensive exomesSupport for Both Short and Long Read Applications:
Optimized protocols for both Illumina-style short-read sequencing and long-read technologies like PacBio and Oxford Nanopore
Consistent Results:
Dramatically reduced inter-operator variability and robust performance across repeated runsUniform Coverage:
Even coverage across challenging regions, including high-GC content areasMaximum Throughput: Process up to 480 exomes simultaneously with pooled libraries with flexible batching
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VoltaHyb’s Expanding App Menu
At Volta, we’re continually growing our support for hybrid capture workflows across both short- and long-read sequencing platforms.
On the short-read side, Callisto currently supports IDT xGEN v2 chemistry, as well as Twist’s standard v2 and Fast chemistries. For long-read applications, we support PacBio HiFi enrichment based on Twist’s standard v2 chemistry.
There are more Apps coming to the VoltaHyb menu, and we’re always listening to our users. If there’s a hybrid capture chemistry you’d like to see automated on Callisto, let us know—we’d love to hear from you.
for Twist, v2 standard
The revolution in genomic sample preparation is here. By bringing the push-button experience of a sequencer to targeted sequencing workflows, Volta Labs is transforming how laboratories approach hybridization capture. The choice is no longer between inconsistent manual methods and complex automation platforms that require dedicated engineering resources. With Callisto and VoltaHyb, you can achieve consistent, high-quality results without specialized training or extensive method development.
Ready to experience the difference? Contact our team today to learn how the VoltaHyb powered Hybridization Capture can enhance your targeted sequencing workflows and accelerate your discoveries.
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Ready to innovate with us?
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Automating the Last Mile of Targeted Sequencing Workflows on Callisto
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