Recap: Udayan Umapathi at SLAS2025
Volta's Founder and CEO Udayan Umapathi presented at SLAS2025 - he shared how Volta Labs has re-engineered sample preparation with the Callisto™ Sample Prep System. Callisto addresses existing sample prep challenges to achieve millimeter-level precision in droplet manipulation on an open reaction surface with a true walk-away platform. Udayan presented during the Novel Micro and Nanoscale Liquid Handling and Applications session with a behind-the-scenes look at the technology that drives sample prep innovation at Volta. Check out this clip from the presentation:
During his presentation, Udayan showcased how this benchtop instrument provides precise magnetic field and temperature control directly on its open surface, facilitating complex operations such as paramagnetic bead-based sample purification, double-sided size selection, and temperature-dependent enzymatic reactions like nucleic acid fragmentation and ligation.
This design significantly reduces reliance on tubes and pipette tips, minimizing plastic waste and streamlining the entire workflow. Callisto comes equipped with a suite of preloaded apps, capable of performing nucleic acid extraction, long- and short-read library prep, and targeted enrichment on a single platform. With less than 30 minutes of user set-up and hands-on time, Callisto offers a true push-button, walk-away experience, processing up to 24 samples in parallel.
From our Founder: the Technology Behind Callisto
About SLAS2025
SLAS, the Society for Laboratory Automation and Screening, is an annual International Conference and Exhibition focusing on convergence of technology and discovery in life sciences, emphasizing laboratory automation, innovation, and analytics.
Callisto enables labs to go from sample to data efficiently and quickly
- Significantly reduces hands-on time with true, walk-away operation
- Preloaded apps ready to run day one - no programming or optimization required
- Scalable and flexible, supporting up to 24 reactions per run
- No need for a dedicated user or skilled operator
If you weren't able to attend SLAS2025, we'd love to connect with you virtually to learn more about your NGS sample prep needs and how Callisto can support your lab.
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Introducing VoltaHyb:
Automating the Last Mile of Targeted Sequencing Workflows
The Volta Labs team is revolutionizing critical targeted sequencing workflows with the introduction of the VoltaHyb™ suite of Apps and kits for the Callisto™ Sample Prep System. Designed to enrich your targets with confidence every single time, the Callisto platform brings unmatched workflow simplicity to hybridization capture. With Callisto, users no longer need to rely on multiple lab instruments (heated blocks, magnetic racks, vortexers) or perform time-sensitive heated transfer steps - such complex steps are abstracted away from the end user. Furthermore, Callisto's unique architecture enables precise magnetic bead manipulation coupled with uninterrupted and uniform temperature control during the hybrid capture enabling consistent enrichment performance.
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Callisto reduces sequencing redo rates to less than 3% while minimizing sample loss throughout the capture process. This breakthrough approach enables reliable targeted sequencing even for challenging applications where conventional tools struggle. These advantages extend across both long and short read-based hybrid capture workflows.
The scalable architecture of the Callisto system enables flexible throughput, with the capacity to process up to 96,000 exomes per year or 48,000 PacBio HiFi samples annually. Whether you're running a small research lab or a high-volume testing facility, Callisto adapts to your needs with flexible batch sizes and consistent performance.
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Key Benefits
of VoltaHyb for Hybridization Capture:
Reduced Sequencing Costs:
Lower sample preparation and sequencing costs by minimizing reruns (<3% redo rates).Fully Automated Workflow:
Enables complete walk-away automation for hybridization, capture, washes, and PCR setupBroad Panel Compatibility:
Works with panels of all sizes, from small targeted panels to comprehensive exomesSupport for Both Short and Long Read Applications:
Optimized protocols for both Illumina-style short-read sequencing and long-read technologies like PacBio and Oxford Nanopore
Consistent Results:
Dramatically reduced inter-operator variability and robust performance across repeated runsUniform Coverage:
Even coverage across challenging regions, including high-GC content areasMaximum Throughput: Process up to 480 exomes simultaneously with pooled libraries with flexible batching
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VoltaHyb’s Expanding App Menu
At Volta, we’re continually growing our support for hybrid capture workflows across both short- and long-read sequencing platforms.
On the short-read side, Callisto currently supports IDT xGEN v2 chemistry, as well as Twist’s standard v2 and Fast chemistries. For long-read applications, we support PacBio HiFi enrichment based on Twist’s standard v2 chemistry.
There are more Apps coming to the VoltaHyb menu, and we’re always listening to our users. If there’s a hybrid capture chemistry you’d like to see automated on Callisto, let us know—we’d love to hear from you.
for Twist, v2 standard
The revolution in genomic sample preparation is here. By bringing the push-button experience of a sequencer to targeted sequencing workflows, Volta Labs is transforming how laboratories approach hybridization capture. The choice is no longer between inconsistent manual methods and complex automation platforms that require dedicated engineering resources. With Callisto and VoltaHyb, you can achieve consistent, high-quality results without specialized training or extensive method development.
Ready to experience the difference? Contact our team today to learn how the VoltaHyb powered Hybridization Capture can enhance your targeted sequencing workflows and accelerate your discoveries.
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Ready to innovate with us?
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Automating the Last Mile of Targeted Sequencing Workflows on Callisto
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